Prevalence of helicobacter pylori infection and clinical characteristics in immune thrombocytopenia patient at St. Paul’s Hospital Millennium Medical College Addis Ababa from September 2016 to June 2019

Abstract

Abstract Background H.Pylori infection is highly prevalent in ITP patient and its eradication has been shown to induce response. Helicobacter pylori has also been postulated to play a role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP) H.Pylori is highly prevalent in Ethiopia with adult prevalence of 52.2%.There is no study done assessing the prevalence of H.Pylori ITP patient in Ethiopia and compering the clinical characteristic between H.Pylori infected and non-infected groups in ITP patent in Ethiopia. METHOD A retrospective study of adult patients seen at St Paul hospital millennium medical college Department of Internal Medicine study in hematology unit from September 2016 to June 2019. A total of 43 patient were included in assessing prevalence of H.Pylori infection. RESULT From the 43 immune thrombocytopenia patient identified H.Pylori infection was found in 9/43(20.9%) by H.Pylori stool Ag , Mean age at diagnosis was 33.63±4.975 age ranges (16- 75) and mean age in H.Pylori negative and positive patient is [34.91 vs 28.78]. The ratio male to female is 1:3.3 the mea platelet count of 18,000 with 67.4% have a count have a count <30, 000. Majority of patient (79.1%) presented with symptomatic thrombocytopenia. Muco cutaneous bleeding occur in 62.8%. complete and partial response was seen in 83.7% .There is no significant difference in platelet count , bleeding type and Gender predominance in H.Pylori infected and none infected group . CONCLUSION ITP is majorly a disease of young females in Ethiopia. And the prevalence of H.Pylori infection is in ITP patient a lower than the general prevalence .most of patient presented with low platelet count with bleeding .There no major difference in clinical characteristics between H.Pylori infected and non-infected group . Most patient have response to treatment