Study of the 99th Percentile Value of High Sensitivity Cardiac Troponin Level in Healthy Addis Ababa Population, Addis Ababa, Ethiopia, July, 2022.

Abstract

Abstract Background: The use of high sensitivity cardiac troponin (hs-cTn) test has led to early diagnosis and management of ACS which lead to an invaluable armament to clinician. These values are extrapolated from the normal healthy individuals applying upper level of the 99 percentile. Diagnosis, management and prognostication of variety of cardiovascular disorders (CVD) specifically acute coronary syndromes (ACS) had been one of breakthroughs in the field of cardiology. However, their use should be based on comparison with normal range values obtained from the population, and it’s considered abnormal when the value is more than the 99th percentile. To date, there are no such nomograms in Ethiopia. Hence, this research was conducted to determine hs-cTn values and associated factors in healthy adults as well prevalence of cardiovascular factors in apparently healthy adults. Method: A prospective study was conducted to determine the 99th percentile level of high sensitive cardiac troponin (hs-cTn) assay in healthy Addis Ababa population. A total of 210 apparently healthy in the primary samples were included for screening out of which 120 were identified as healthy.The general population 99th percentile hs-cTn I level was found to be 45.74 pg/ml, with statstically significant difference between male and female groups (p=0.002) as well with incresing age (p=0.012) with age group ≥65 having higher values.. Conclusion and Recommendation: The 99th percentile value of hs-cTn value of Addis Ababa healthy population determined to be 45.74 pg/ml with 44.97 pg/ml & 31.93 pg/ml for male and female respectively. Key words: High sensitive Cardiac Troponin assay , 99th percentile cTn, prospective study, SPHMMC, ALERT center/hospital, Addis Ababa, Ethiopia.