ASSESSMENT OF HEALTH-RELATED QUALITY OF LIFE AND ITS ASSOCIATED FACTORS AMONG MULTI DRUGRESISTANT TUBERCULOSIS TREATED PATIENTS ON FOLLOW UP AT ST. PETER’S SPECIALIZED HOSPITAL AND ALERT HOSPITAL ADDIS ABABA, ETHIOPIA

Abstract

Abstract Background: Multidrug-resistant tuberculosis has become a major public health problem, especially in developing countries. Despite the considerable attention given to traditional microbiological and clinical indicators, the effect of Multidrug-resistant tuberculosis on the Health related quality of life of patients has not been well investigated in Ethiopia. Objectives: The primary objective of the study is to assess health-related quality of life and the factors associated with it in patients who have completed treatment for Multidrug-resistant tuberculosis at St. Peter’s specialized hospital and ALERT hospital Addis Ababa, Ethiopia. Method: A hospital based cross-sectional study was done to assess health-related quality of life among patients who had completed Multidrug-resistant tuberculosis treatment at St Peter’ s specialized hospital and ALERT hospital. The 36-Item Short Form Survey (SF-36), a health related quality of life assessment tool was used to measure the dependent variables. The data was analyzed using Statistical Package for Service Solution Version 27 (SPSS 27). A Physical component summary (PCS) score of less than 54.1 and mental component summary (MCS) score of less than 49.5 on SF-36 Survey was considered to be suggestive of function Impairment and at risk of depression respectively. Bivariate and multivariate analysis between health-related quality of life and the independent variables was performed. Result: A total of 187 patients were interviewed, out of which 55.1% and 67.4 % had a mean PCS and MCS scores below population based normative scores respectively. Retroviral infections, type of anti-TB regimen, duration after completing treatment were predictive of affected MCS score. Conclusion & recommendations: This study showed that MDR-TB has a substantial impact on patients health related quality of life. Therefore interventional programs to enhance HRQoL should be implemented at various stages treatment and also post treatment for MDR-TB patients