RISK FACTORS AND TREATMENT OUTCOMES OF MDR TB PATIENTS IN ST. PETER TB SPECIALIZED HOSPITAL IN THE LAST 5 YEARS

Abstract

SUMMARY Background: TB is an infectious disease caused by the bacillus Mycobacterium tuberculosis. It typically affects the lungs (pulmonary TB) but can also affect other sites (extra pulmonary TB). It is the ninth leading cause of death worldwide and the leading cause from a single infectious agent, ranking above HIV/AIDS. Beside this, MDR TB is defined as TB that is resistant to both isoniazid (INH) and rifampicin (RIF), two of the first-line drugs used in treating pulmonary tuberculosis. Both TB and MDR TB are the global threats that really need a special attention on the prevention and treatment. As part of the globe, Ethiopia is one of the high TB burdened country in the world. Therefore, the objective of this study will encompass in reveling the risk factors and treatment outcomes of MDR TB. METHODS AND MATERIALS: The source population for this study is patients who are admitted and had follow up to St. Peter TB specialized hospital as a case MDR TB in the past 5 years. An institution based retrospective Cohort study design and a systematic random sampling procedure will be conducted to select a fair representative sample from the hospitalized patients. 374 subjects will be selected for the study. To collect data, a self-administered questionnaire will be used as a check-list to extract data’s from the medical records. After data is collected, it will be entered into a computer and analyzed using SPSS version 21.0 statistical software. Multivariable logistic regression with 95% CI at P ≤ 0.05 will be used to determine factors associated to acquisition of MDR TB. Finally result will be presented in text and graphs and communicated to all concerned bodies. WORK PLAN AND BUDGET: Total cost of the research project is estimated to be 4924.00 birr. Proposal work and field preparation will be completed till Feb 2018, data will be collected Feb-Jun 2018 and analysis, compilation and report write up will be July 2018. KEY WORDS: TB, MDR-TB